Micronomycin sulfate

Name	Micronomicin Sulfate
Synonyms	Micronomicin Sulfate MICRONOMYCIN SULFATE MICRONOMICIN SULFATE Micronomycin sulfate sulfate,d-1-6))-2-deoxy Micronomicin sulfate JAS1998 6'-N-METHYLGENTAMICIN C1A HEMIPENTASULFATE streptamine,o-2-amino-2,3,4,6-tetradeoxy-6-(methylamino)-alpha-d-erythro-hexop yranosyl-(1-4)-o-(3-deoxy-4-c-methyl-3-(methylamino)-beta-l-arabinopyranosyl-( Streptamine, O-2-amino-2,3,4,6-tetradeoxy-6-(methylamino)-alpha-D-erythro-hexopyranosyl-(1-4)-O-(3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranosyl-(1-6))-2-deoxy-, sulfate, D- D-Streptamine, O-2-amino-2,3,4,6-tetradeoxy-6-(methylamino)-a-D-erythro-hexopyranosyl-(14)-O-[3-deoxy-4-C-methyl-3-(methylamino)-b-L-arabinopyranosyl-(16)]-2-deoxy-, sulfate (salt) (9CI)
CAS	66803-19-8
EINECS	1308068-626-2
InChI	InChI=1/C20H41N5O7.H2O4S/c1-20(28)8-29-19(14(27)17(20)25-3)32-16-12(23)6-11(22)15(13(16)26)31-18-10(21)5-4-9(30-18)7-24-2;1-5(2,3)4/h9-19,24-28H,4-8,21-23H2,1-3H3;(H2,1,2,3,4)/t9-,10+,11-,12+,13-,14+,15+,16-,17+,18+,19+,20-;/m0./s1

Molecular Formula	C20H43N5O11S
Molar Mass	561.65
Melting Point	>205°C (dec.)
Boling Point	667℃
Flash Point	>110°(230°F)
Water Solubility	Freely soluble in water
Solubility	DMSO (Very Slightly, Heated, Sonicated), Water (Slightly)
Vapor Presure	1.19E-20mmHg at 25°C
Appearance	Solid
Color	White to Pale Yellow
Storage Condition	Hygroscopic, Refrigerator, under inert atmosphere
Stability	Hygroscopic
Use	Belongs to antibiotics
In vitro study	Micronomicin has a potent antibacterial activity, it is active against Staphylococcus aureus FDA 209 P, Staphylococcus aureus with the minimal inhibitory values of 0.01 μg/ml. It is also against Escherichia coli St.M. 589, Baker 2, F 14-BK, and R5/W677 with the minimal inhibitory values of 0.75 μg/ml, 0.3 μg/ml, 0.03 μg/ml and 0.03 μg/ml. And it is active against Pseudomonas aeruginosa strains and lebsiella pneumoniae strains (MICs = 0.03-17.5 μg/ml).
In vivo study	Micronomicin sulfate is highly active against various bacterial infections in mice, and has an intravenous acute LD 50 in mice of 93 mg/kg.Micronomicin sulfate (intravenous injection; 4-100 mg/kg; 30 days) is injected for subacute toxicity study. The wistar rats dies at the dose level of 100 mg/kg (10 out of 30 animals): renal disorders and ataxia. The renal histological disorders occurrs mainly at the dose levels of 25 mg/kg and over. Animal Model: Wistar rats Dosage: 4, 10, 25, 63 mg/kg and 100 mg/kg Administration: Intravenous injection; 30 days Result: Led to death of rat at 100 mg/kg.

RTECS

WK2196000

Raw Materials

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CAS: 66803-19-8
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Micronomycin sulfate

Raw Materials for Micronomycin sulfate

Starch potato
Hydrochloric acid

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